Clinico-pathological profile of acute promyelocytic leukaemia at Al-Amal Oncology-Haematology Centre, Qatar.

All-trans retinoic acid induced thrombocytosis in a patient with acute promyelocytic leukaemia.

The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia

Background: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and generating mature MDDC either alone or in combination with other cytokines. Objective: To compare effe...

MYELOID NEOPLASIA The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling

1Department of Microbiology, Institute of Clinical Biochemistry and Centre of Molecular Biology and Neuroscience, Oslo University Hospital and University of Oslo, Rikshospitalet, Oslo, Norway; 2Department of Biomedicine, University of Bergen, Bergen, Norway; 3Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; 4Section for Haematology, Department o...

Clinical applications of molecular haematology: an overview.

Haematological disorders are getting more and more molecularly defined. This is specially so in the field of haematological malignancies. The molecular understanding has helped in fine-tuning the diagnosis, prognosis and management. The tests are becoming widely available and they enjoy both sensitivity and specificity. Following is an overview of clinical applications of molecular haematology,...

Pathogenesis and management of the bleeding diathesis in acute promyelocytic leukaemia.

Life-threatening bleeding, which remains a challenging complication of acute leukaemia, is particularly characteristic of the subtype, acute promyelocytic leukaemia (APL). The clinical picture and laboratory abnormalities are most compatible with the diagnosis of disseminated intravascular coagulation (DIC). Evidence for diffuse activation of the coagulation system, hyperfibrinolysis and system...